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四环流体在透性上的光 在细胞内寄生虫周围的膜的研究.

H G DUBUY, H G DUBUY, F RILEY

    Science (New York, N.Y.)
    |July 10, 1964
    PubMed
    概括

    宿主细胞膜创建一个屏障,防止四环素到达细胞内寄生虫. 这种选择性透现象为研究这些宿主衍生的边界和寄生虫相互作用提供了一种新方法.

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    科学领域:

    • 微生物学 微生物学
    • 细胞生物学 细胞生物学
    • 免疫学 免疫学 免疫学

    背景情况:

    • 宿主细胞的细胞分裂可以封闭细胞内病原体,如原生动物,细菌和病毒.
    • 在这些病原体周围形成了一个细胞体内边界,影响它们与宿主细胞环境的相互作用.

    研究的目的:

    • 为了研究围绕着 fagocytosed 病原体的宿主衍生边界的透性.
    • 探索四环素排除的潜力,作为一种研究这些边界的选择性透性的方法.

    主要方法:

    • 使用光抗生素四环素来评估病原体的可见性.
    • 在宿主细胞死亡时观察病原体光的变化.

    主要成果:

    • 当细胞内病原体被宿主边界封闭时,它们保持非光 (未被四环素透).
    • 在宿主细胞死亡时释放的细胞外病原体和细胞内病原体变得光.
    • 对于某些细胞外寄生虫在全血清存在时,观察到类似的四环素排除.

    结论:

    • 围绕着 fagocytosed 病原体的细胞体内边界很可能是宿主起源.
    • 这一边界表现出选择性的透性,限制了四环素的进入.
    • 环素排斥现象为研究宿主衍生膜的选择性透性和与病原体的相互作用提供了一个新的工具.
    关键词:
    巴西卢斯·塞雷乌斯 (Bacillus Cereusus) 是一个细胞膜 细胞膜埃舍里奇亚科利 (Eschericia Coli) 是一个古老的城市.实验室研究实验室研究鲜花的芳香 鲜花的芳香无透性是一种可穿透性.细胞形成 细胞形成萨尔莫内拉型霍萨 (SALMONELLA TYPHOSA) 是一种鱼类.一个四环环素四环素.毒素等离子体 毒素等离子体脊椎动物的病毒

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