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纤维素第十种III型模块的三维结构:对RGD介导相互作用的洞察力
A L Main1, T S Harvey, M Baron
1Department of Biochemistry, University of Oxford, England.
Cell
|November 13, 1992
概括
纤维肌菌素的结构
科学领域:
- 生物化学 生物化学
- 结构生物学 结构生物学
- 分子生物学分子生物学
背景情况:
- 纤维素第十种III型模块在细胞粘附中发挥作用.
- 了解它的结构对于阐明它的功能至关重要.
研究的目的:
- 确定第十个Fibronectin III型模块的溶液结构.
- 描述其结构特征及其与功能的关系.
主要方法:
- 核磁共振 (NMR) 光谱法用于确定溶液结构.
- 分析β链排列和疏水性核心包装的分析.
主要成果:
- 纤维菌素模块采用类似于免疫球蛋白域的折叠,具有七个β链,形成两个反平行板.
- 一个紧的疏水核是由两个β片的保存残留物形成的.
- 在一个灵活的循环上,Arg-Gly-Asp (RGD) 细胞粘附序列被溶剂暴露.
结论:
- 确定的结构提供了关于纤维素菌素细胞粘附性质的分子基础的见解.
- 在移动循环上RGD序列的可访问性支持其功能作用.
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