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在心脏移植接受者的运动期间异常的神经内分泌反应
R W Braith1, C E Wood, M C Limacher
1Center for Exercise Science, College of Medicine, University of Florida, Gainesville 32610.
Circulation
|November 1, 1992
概括
心脏移植接受者在艰苦的运动过程中表现出过度的神经内分泌反应,这是由于心脏机械受体信号丢失. 这种慢性神经内分泌过活性可能会导致这些患者的高血压.
科学领域:
- 心血管生理学心血管生理学
- 神经内分泌学神经内分泌学
- 移植医学 移植医学
背景情况:
- 运动通常刺激神经内分泌活动,由心脏机械受体 afferents 缓冲.
- 整形心脏移植切断了这些关联通路,可能导致体力活动期间的反应过度.
研究的目的:
- 与对照组相比,研究心脏移植接受者对运动的神经内分泌反应.
- 为了确定心脏机械受体 afferents的损失是否影响神经内分泌调节在体力炼期间.
主要方法:
- 对比了11名心脏移植接受者和11名对照者在分级和次最大运动 (40%和70%的峰值功率) 期间.
- 测量了上腺素,压素,素活性,心房 natriuretic ,血管新生素II 和在休息和运动期间的血水平.
- 评估心率,感知劳动力和血体积变化.
主要成果:
- 心脏移植患者的静止血激素活性和心房 natriuretic 的升高.
- 神经内分泌激素的相对变化在40%的峰值功率下类似,但在70%的峰值功率和分级运动期间的接受者中更大.
- 两组之间没有观察到心率,感知劳动力或血体积减少的显著差异.
结论:
- 切除心脏机械受体附属体可能会导致心脏移植受体无阻的神经内分泌刺激.
- 慢性神经内分泌过活性可能存在于门诊心脏移植接受者.
- 这种过度活跃,改变体积调节,可能与环素毒性一起导致高血压.
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