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在围产期内心周压的变化
D A Grant1, C S Kondo, J E Maloney
1Cardiovascular Research Group, University of Calgary, Alberta, Canada.
Circulation
|November 1, 1992
概括
在胎儿羔羊中启动通风可显著降低心周压,增加左心室预负荷并增强缩功能. 这表明降低心周压在增加出生时心脏输出方面起着至关重要的作用.
科学领域:
- 心脏病学 心脏病学
- 周产期生理学 周产期生理学
- 胎儿的发育 胎儿的发育
背景情况:
- 围产期涉及到心脏功能的显著生理变化.
- 了解周围组织对胎儿心脏功能的影响至关重要.
研究的目的:
- 研究胎儿心脏周围的组织如何影响胎儿心脏的舒张和收缩功能.
- 为了分析胎儿左心室在围产期过渡期间的压力-直径关系.
主要方法:
- 利用部分分娩的胎儿羔羊,对左心室直径,心周压力和左心室压力进行仪器仪表.
- 在闭胸条件下记录压力-直径关系,通风后,以及心周收缩.
- 评估左心室的扩张压遵守性和收缩性,使用末端扩张压力和跨壁末端扩张压力.
主要成果:
- 通风导致心周压力显著下降 (48%).
- 左心室直径在通风后的每一个末端透气压时都增加,这表明透气遵守改善了.
- 由于增加预负荷,左心室缩功能得到改善,而不是收缩能力改变.
结论:
- 周心组织提高压力,并限制胎儿左心室预负荷.
- 开始通风降低心周压力,增加预负荷和缩功能.
- 产后心周压的降低可能会通过弗兰克-斯塔林机制增强心脏输出.
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