人体胃肠道和左内乳腺动脉之间血管运动控制的差异
H Buikema1, J G Grandjean, S van den Broek
1Department of Pharamcology/Clinical Pharmacology, University Hospital Groningen, The Netherlands.
Circulation
|November 1, 1992
概括
胃脉动脉和左内乳腺动脉对一些血管活性物质表现出类似的反应,但胃脉动脉对布拉迪基宁具有更大的放松,这表明冠状动脉旁路移植的内皮功能可能存在差异.
科学领域:
- 血管外科 血管外科
- 心血管研究研究心血管研究
- 内皮细胞功能 内皮细胞功能
背景情况:
- 内部乳腺动脉移植提供优越的长期通透性,相比静脉移植.
- 动脉和静脉血管之间的内皮功能差异也与此有关.
- 胃动脉越来越多地用于冠状动脉旁路移植,因为与内部乳腺动脉的相似之处.
研究的目的:
- 为了比较胃腹动脉和左内乳腺动脉移植的内皮反应.
- 研究它们对各种血管活性物质的反应.
主要方法:
- 从接受冠状动脉旁路手术的患者中采集了胃腹动脉和左侧内部乳腺动脉.
- 血管环受到了器官浴的实验.
- 测量了对甲胆,酸盐和布拉迪基宁的放松反应.
主要成果:
- 这两个动脉对甲胆和酸盐的放松反应都类似.
- 布拉迪基宁诱导了胃动脉环的显著放松,但在左侧内部乳腺动脉环中没有.
- 观察到年龄和最大的甲胆诱导放松在左侧内部乳腺动脉环之间存在负相关性.
结论:
- 对甲胆和酸盐的类似反应表明,两动脉中的L-氨酸通路活性相似.
- 不同的布拉迪基宁反应可能表明胃动脉中明显的前列腺素代谢.
- 在左内乳腺动脉的年龄依赖的放松,不像胃动脉,被注意到.
相关概念视频
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