对威斯康星大学修改的溶液进行组合分析,以延长心肌保护. 对左心室压力-体积关系的研究
W Ko1, J A Zelano, W D Lazenby
1Cardiothoracic Surgery Research Laboratory, New York Hospital-Cornell University Medical College, New York 10021.
Circulation
|November 1, 1992
概括
威斯康星大学 (UW) 的解决方案对于心脏的保存至关重要. 省略基乙烯粉或改变电解质会对透缩功能产生负面影响,而拉芬对保持心脏功能是不必要的.
科学领域:
- 心脏病学 心脏病学
- 器官的保存 器官的保存
- 生物化学 生物化学
背景情况:
- 威斯康星大学 (UW) 的解决方案是延长心脏保存的标准.
- 这项研究调查了特定的UW解决方案组件的必要性.
研究的目的:
- 评估从UW溶液中去除四个成分对心脏保存的影响.
- 确定在低温储存期间维持左心室功能所必需的要素.
主要方法:
- 狗狗的心脏使用修改后的UW溶液保存了6个小时.
- 评估左心室功能是通过测量静缩和静缩参数来评估的.
- 评估的UW溶液:未经修改,电解质成分改变 (UW-E),化物替代 (UW-L),没有拉芬酸 (UW-R),没有基乙烯粉 (UW-HS).
主要成果:
- 在任何修改后的UW组中都没有观察到缩功能显著下降.
- 在UW-E和UW-HS组中发生了显著的扩张顺应性恶化.
- UW-L显示了一种趋势,即扩张力遵守性降低,而UW-R保留了扩张力功能.
结论:
- 基乙基粉和细胞内电解质平衡对于维护透缩功能至关重要.
- 拉菲诺斯的缺失没有影响心脏保存结果.
- 与其他固体器官保存研究相比,用化物取代乳酸对心脏功能产生最小的不良影响.
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