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相关实验视频

Updated: Jun 21, 2026

An Isolated Working Heart System for Large Animal Models
09:45

An Isolated Working Heart System for Large Animal Models

Published on: June 11, 2014

用威斯康星大学溶液保存的心脏中的功能, perfusion,代谢和组织学的评估.

M P Nutt1, B L Fields, L A Sebree

  • 1Department of Surgery, University of Wisconsin Hospital and Clinics, Madison.

Circulation
|November 11, 1992
PubMed
概括
此摘要是机器生成的。

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使用威斯康星大学溶液的连续 perfusion 保存保持心脏功能与对照组相比. 冷藏导致心脏功能,输液和组织学显著降低.

科学领域:

  • 心脏病学 心脏病学
  • 器官的保存 器官的保存
  • 手术技巧 手术技巧

背景情况:

  • 威斯康星大学的解决方案是延长心脏保存的有希望的药物.
  • 这项研究旨在比较心脏冷藏和 perfusion 保存方法.

研究的目的:

  • 评估连续输液保存与冷藏24小时心脏保存的有效性.
  • 为了评估心脏功能,输液,新陈代谢和组织完整性,在不同的保存方法后.

主要方法:

  • 子的心脏被分为三个组:控制 (即时再注射),持续 perfusion 保存和冷藏.
  • 心脏经历了24小时的保存,随后进行了30分钟的再注血.
  • 左心室缩压 (LVSP) 测量了心脏功能.
  • 201Tl和14C-酸盐自辐射分别评估了输液和新陈代谢.

主要成果:

  • 持续输液心脏显示LVSP与对照组相比 (112.2 +/- 6.0对134.8 +/- 2.1mm Hg).
  • 冷藏心脏表现出显著受损的LVSP (36.7 +/- 6.0 mm Hg,p < 0.001).
  • 连续 perfusion 导致轻微的低 perfusion 和组织学损伤 (26.4%),而冷藏显示广泛的损伤 (51.7%).

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Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism
09:10

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Published on: January 12, 2019

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography
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Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography

Published on: October 11, 2022

相关实验视频

Last Updated: Jun 21, 2026

An Isolated Working Heart System for Large Animal Models
09:45

An Isolated Working Heart System for Large Animal Models

Published on: June 11, 2014

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism
09:10

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Published on: January 12, 2019

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography
08:21

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography

Published on: October 11, 2022

结论:

  • 连续输注4°C的威斯康星大学溶液有效地保持心脏功能.
  • 冷藏会导致严重的功能,代谢和组织学损害.
  • perfusion 保存为冷藏提供了一种优越的替代方案,可以长时间保存心脏.