在低温血液中氧化血球分离心脏停止停止
W L Holman1, R D Spruell, S B Digerness
1Division of Cardiothoracic Surgery, University of Alabama, Birmingham.
Circulation
|November 1, 1992
概括
在低温心期间,氧气在前30秒内与血红蛋白分离. 心肌只能接收物理溶解的氧气,而不是与血红蛋白结合的氧气.
科学领域:
- 心血管生理学心血管生理学
- 生物化学 生物化学
背景情况:
- 冠状动脉鼻腔血液在初始的低温心肌输液中被脱.
- 尽管血红蛋白在低温和性pH下具有很高的氧化亲和力,但这种情况仍然发生.
研究的目的:
- 在低温心性停止期间量化氧血球分离.
- 在心脏期间评估向肌肉心脏的氧气输送.
主要方法:
- 在大动脉根交叉紧过程中使用4°C的类血液心脏的溶液.
- 在输液过程中在特定时间点收集对合的大动脉根和冠状动脉鼻血液样本.
- 在采集的样本中测量了血红蛋白和和氧气 (PO2) 的部分压力.
主要成果:
- 大动脉根的血红蛋白和率在整个过程中保持在100%.
- 在输液后5秒内,冠状动脉鼻血红蛋白和率显著下降至63.0%-66.5% (p < 0.05).
- 与大动脉根样本 (p < 0.05) 相比,冠状动脉PO2在5秒 (31-39 mm Hg) 后显着较低.
结论:
- 在非 perfused 阶段的低温,性心肌中,氧气与血红蛋白分离.
- 输注期间心肌氧的输送仅限于心溶液中物理溶解的氧气.
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