消除慢性体积过载的情况. 在Fontan修复后立即影响全身心室的舒张功能
M Gewillig1, W Daenen, A Aubert
1Laboratory of Experimental Cardiology, O/N Gasthuisberg, University of Leuven, Belgium.
Circulation
|November 1, 1992
概括
在Fontan电路创建后的早期,心室壁厚度增加会损害由于粘度和惯性而导致早期的透气填充,而不是影响放松. 腹腔吸收减弱,但放松性会随着时间的推移恢复.
科学领域:
- 心脏病学 心脏病学
- 儿童心脏病学 儿童心脏病学
- 心脏外科手术 心脏外科手术
背景情况:
- 患有单心室心脏的患者接受Fontan电路创建,以消除慢性心室体积过载.
- 这种手术减少了心室腔的大小,但可以导致手术后心室壁的不适当加厚.
- 对心室的透缩性质的影响仍然不太清楚.
研究的目的:
- 为了研究慢性体积过载的急性去除后心室的透缩性质.
- 为了确定心室壁厚度增加是否会影响放松或早期填充.
主要方法:
- 在混血犬中使用修改后的Blalock-Taussig分流器创建了一个慢性体积过载模型.
- 冲刺被皮肤封闭,左心室尺寸和壁厚度被测量使用心声回声学.
- 记录了同体气压衰减 (tau),同体气放松时间 (A2-MVO) 和达到最小左心室压力 (A2-LVPmin) 的时间.
主要成果:
- 闭塞后一个小时,左心室尺寸显示不完全恢复到基线,后壁厚度增加.
- 腹腔松 (tau) 保持不变,但早期填充是的,表明腹腔吸收减少.
- A2-MVO和A2-LVPmin在分流封闭后长达一周的时间内显著增加.
结论:
- 在体积过载去除后的早期,增加的壁厚不会损害心室放松.
- 由于质量与体积的比率增加,粘度和惯性会损害早期心室填充.
- 体积诱导的缩在一个月内回归,早期心室填充指数恢复.
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