动脉样硬化和血栓形成之间的关系
1Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.
Circulation
|December 1, 1992
概括
动脉样硬化和血栓形成有着共同的分子机制. 了解这些在动脉动脉生成中的血栓决定因素,可以更清楚地了解疾病的发展.
科学领域:
- 心血管生物学 心血管生物学
- 血栓形成研究研究
- 动脉样硬化病原体的产生
背景情况:
- 动脉样硬化和血栓形成之间的联系早已确立,但在分子层面上了解得很少.
- 从历史上看,这种关联依赖于观测数据,缺乏机械洞察力.
研究的目的:
- 阐明连接动脉样硬化和血栓形成的分子和细胞机制.
- 探索在动脉形成中的血栓形成因子的调节和调节.
主要方法:
- 综述已知血栓形成决定因素 (血小板,纤维素,纤维解酶) 与动脉样硬化之间的相关性.
- 分析细胞因子,生长因子和脂蛋白 (特别是脂蛋白) 调节血栓性因素.
主要成果:
- 讨论了主要的血栓形成决定因素和动脉样硬化之间的关联.
- 突出了细胞因子,生长因子和异位性脂蛋白在调节血栓性因素中的作用.
- 解释了血栓性决定因子由脂蛋白的调节.
结论:
- 新兴的分子和细胞机制澄清了动脉生成的血栓性基础.
- 提供了对血栓形成如何导致动脉样硬化发展的基本理解.
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