概括
当免疫细胞不兼容时,免疫细胞可以杀死瘤细胞. 这种免疫反应需要细胞聚合,但在体外细胞毒性方面,与基因不相容细胞之间的密切接触是必不可少的.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 在瘤学瘤学.
背景情况:
- 免疫淋巴结细胞对瘤细胞表现出细胞毒性作用.
- 基因相容性抗原,特别是H-2型,在免疫识别中发挥作用.
研究的目的:
- 研究通过淋巴细胞对瘤细胞进行介导的体外细胞毒性要求.
- 确定细胞聚合和基因不相容性在免疫细胞介导的瘤细胞杀死中的作用.
主要方法:
- 免疫淋巴结细胞和瘤细胞的组织培养.
- 使用热失活的子抗血清或植物血凝素诱导淋巴细胞聚合.
- 对瘤点细胞的细胞毒性影响的观察.
主要成果:
- 具有外来H-2抗原的免疫淋巴结细胞对不兼容的瘤细胞显示出显著的细胞毒性.
- 在瘤细胞周围的正常异构和半异构淋巴细胞的聚合也诱导了细胞毒性.
- 异位淋巴结细胞没有诱导细胞毒性,这表明基因组不相容性是必要的.
结论:
- 淋巴细胞聚合是必要的,但对于体外细胞毒性来说不够.
- 基因不相容细胞之间的密切接触是有效的细胞介导细胞毒性对瘤细胞的关键要求.
相关概念视频
Cell-mediated Immune Responses
Overview
Cells of the Innate Immune Response
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Immune Surveillance by NK Cells and Phagocytes
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...


