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相关概念视频

Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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相关实验视频

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Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery
08:38

Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery

Published on: October 4, 2018

血红蛋白 F 德克萨斯: 玛链变体

R G SCHNEIDER, R T JONES

    Science (New York, N.Y.)
    |April 9, 1965
    PubMed
    概括

    在婴儿中发现了一种新的异常胎儿血红蛋白,血红蛋白F (德克萨斯州). 这种变体涉及特定的氨基酸替代在血红蛋白的玛链.

    科学领域:

    • 生物化学 生物化学
    • 遗传学 是一个遗传学.
    • 血液学 血液学 血液学

    背景情况:

    • 胎儿血红蛋白 (HbF) 对于子宫内的氧气运输至关重要.
    • 血红蛋白结构的变化可能会导致临床影响.

    研究的目的:

    • 为了表征一种新发现的异常胎儿血红蛋白变体.
    • 为了确定血红蛋白F的结构基础 (Texas).

    主要方法:

    • 对带血样本的分析.
    • 对异常血红蛋白的化学结构研究.

    主要成果:

    • 确定了一个异常的胎儿血红蛋白,被指定为血红蛋白F ((德克萨斯州).
    • 在多个相关的婴儿和一个非相关的婴儿中发现.
    • 结构分析显示,在玛链中,酸残留物替代了酸残留物.

    结论:

    • 血红蛋白F ((德克萨斯州) 是胎儿血红蛋白的一个新型结构变体.
    • 已识别的替代提供了对血红蛋白病变的洞察力.
    关键词:
    染色体学 染色体学 染色体学电光学是一种电光学.胎儿血液中的血球蛋白.凝的扩散试验血球蛋白,不正常的情况类蛋白质 (PEPTIDES) 是一种

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