多重危险因素干预试验的高血压成员的功能变化. 种族和治疗效应. 在MRFIT研究小组
W G Walker1, J D Neaton, J A Cutler
1School of Medicine, Johns Hopkins University, Baltimore, Md.
JAMA
|December 2, 1992
概括
高血压有助于功能下降,特别是在黑人男性. 有效的血压控制有利于非黑人个人,但它对黑人男性的影响.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 轻度至中度高血压是渐进性功能丧失的重要危险因素.
- 了解高血压对不同种族群体对功能的影响对于有针对性的干预至关重要.
研究的目的:
- 评估轻度至中度高血压如何导致功能逐渐下降.
- 分析多重风险因素干预试验 (MRFIT) 的功能数据,以评估这些贡献.
主要方法:
- 在5524名高血压男性 (463名黑人,5061名非黑人) 的7年随访期间对互惠肌素倾斜的分析.
- 评估血压控制,年龄,种族和基线血压作为影响功能变化的因素.
- 特殊干预 (SI) 组与常规护理 (UC) 组之间的结果比较.
主要成果:
- 与白人男性相比,黑人男性的功能显著下降 (P < .001).
- 压缩性和压缩性血压升高,以及年龄较大,与较大的功能下降有关 (P < .001).
- 保持压力低于95mmHg与结合组的稳定或改善的功能有关,但在黑人男性中没有观察到这种效果.
结论:
- 有效的血压控制与非黑人个体的稳定或改善的功能有关,而非黑人个体.
- 这些发现凸显了血压管理对于在高血压白人男性中保持功能的重要性.
- 需要进一步的研究来了解血压降低和黑人人群中的功能变化之间的复杂关系.
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