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Updated: Jul 6, 2026

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
08:10

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

通过降低CD8的贡献来选择具有高亲和力对自身MHC的T细胞受体

L A Sherman1, S V Hesse, M J Irwin

  • 1Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.

Science (New York, N.Y.)
|October 30, 1992
PubMed
概括

改变与CD8核受体的T细胞相互作用可以防止具有高自主主要基因相容复合体 (MHC) 亲和力的T细胞的消除. 这种策略产生识别自我MHC加低亲和力的抗原的T细胞,有助于免疫耐受性.

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