概括
巨症患者可能会出现心脏问题,如左心室缩,特别是长期疾病或高生长激素水平. 这些心脏变化可能会在治疗后可逆,这表明特定的杂性心肌病变.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 内部医学 内部医学
背景情况:
- 巨症是一种由生长激素过量引起的疾病,与心血管并发症有关.
- 了解特定的心脏表现及其与疾病严重程度的关系至关重要.
研究的目的:
- 为了研究心脏异常在阿克罗美加患者.
- 确定与心脏功能障碍相关的因素,如疾病持续时间和生长激素水平.
主要方法:
- 使用心声回声学,心声学,压力心电学与 perfusion 扫描,并封闭的放射性同位素左心室血管图.
- 评估了16名患有壮病的患者,评估了心脏结构和功能.
主要成果:
- 六名同时患有高血压或冠状动脉疾病的患者表现出异常,包括左心室质量指数增加和心室功能受损.
- 三名患有长期壮症 (>13年) 或非常高生长激素 (>100 ng/ml) 的患者表现出集中的左心室缩,其中一人也表现出功能障碍.
- 在疾病持续时间较短,生长激素水平较低或治疗后水平正常化的患者中没有观察到心脏异常.
结论:
- 巨症与冠状动脉和高血压心脏病的高患病率有关.
- 一种明显的,潜在的可逆心肌病可能会发生在壮症中,可能是由于长期的疾病或增长激素水平升高.
相关概念视频
Structure of Cardiac Muscles
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Overview of the Heart
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
The heart's structure...
Location and Orientation of the Heart
The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
Imbalances in Cardiac Output
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Heart Failure II: Pathophysiology
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...


