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激活的Cdc42封存c-Cbl,并防止EGF受体降解降解

Wen Jin Wu1, Shine Tu, Richard A Cerione

  • 1Department of Molecular Medicine, Veterinary Medical Center, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA.

Cell
|September 25, 2003
PubMed
概括

Cdc42的激活阻止了EGF受体通过c-Cbl的泛化,这是细胞生长调节的一个关键步骤. 失调导致持续的信号传输和细胞转化.

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