胞体是对抗原交叉呈现有能力的器官
Mathieu Houde1, Sylvie Bertholet, Etienne Gagnon
1Département de pathologie et biologie cellulaire, Université de Montréal, C.P.6128, Succ centre-ville, Montréal, Québec, H3C 3J7, Canada.
Nature
|September 26, 2003
概括
这项研究揭示了体可以独立处理外源抗原以进行交叉呈现,这是启动T细胞对细胞内病原体反应的关键机制.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 抗原的处理和呈现对于免疫反应至关重要.
- 主体组织相容性复合体 (MHC) 类I和II通路通常分离抗原来源.
- 外源抗原通过MHC类I交叉呈现对于CD8+T细胞反应至关重要,但人们对其了解甚少.
研究的目的:
- 阐明交叉呈现背后的细胞机制.
- 调查胞细胞在处理外源抗原中的作用,用于MHC I类表现.
主要方法:
- 研究了体的特性和功能.
- 检查了在抗原交叉呈现中细胞的自给性.
主要成果:
- 体具有抗原交叉呈现的固有能力.
- 这一功能与内细胞网介导的细胞分裂有关.
结论:
- 发酵体是自给自足的有机体,用于异源抗原的交叉呈现.
- 这一发现扩大了我们对天生的免疫机制和抗原处理的理解.
相关概念视频
Phagocytosis
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
Phagocytosis
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells, including...
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells, including...
Immune Surveillance by NK Cells and Phagocytes
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Presenting Cells
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Antigen Processing Pathways
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...


