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Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
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Hsp90的高亲和度构造赋予了Hsp90抑制剂的瘤选择性

Adeela Kamal1, Lia Thao, John Sensintaffar

  • 1Conforma Therapeutics Corporation, 9393 Towne Centre Drive, Suite 240, San Diego, California 92121, USA.

Nature
|September 26, 2003
PubMed
概括

癌细胞中的热冲击蛋白90 (Hsp90) 对药物17-AAG的亲和力比正常细胞高100倍. 这种差异是由于瘤Hsp90处于激活复合体中,提供了潜在的癌症治疗点.

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