多菌炎和皮肤菌炎
Marinos C Dalakas1, Reinhard Hohlfeld
1Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1382, USA. dalakasm@ninds.nih.gov
Lancet (London, England)
|September 27, 2003
概括
炎症性肌肉病变,包括皮肤肌炎和多肌炎,是可治疗的获得性肌肉疾病. 区分这些疾病是有效的免疫治疗和管理肌肉缺血和的关键.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 炎症性肌肉病是可以获得的,可治疗的肌肉疾病.
- 根据不同的特征,它们被分为皮肤肌炎,多肌炎和包括体肌炎.
- 准确的诊断对于有效的管理至关重要.
研究的目的:
- 要区分炎症性肌肉病变的三个主要子集.
- 阐明潜在的病理机制.
- 突出早期诊断和治疗的重要性.
主要方法:
- 临床,组织病理学,免疫学和人口学特征分析.
- 检查病原性通路,包括补体激活和T细胞介导的细胞毒性.
- 对诊断标准和治疗方法的审查.
主要成果:
- 皮肤肌炎涉及微血管病变和补充介导的毛细血管溶解.
- 聚髓炎和包容体肌肉炎的特征是CD8+T细胞入侵和肌肉纤维死.
- 包容体肌肉炎还显示真空形成和粉样质沉积物.
- 像粘附分子和细胞因子这样的分子因素有助于致病的产生.
结论:
- 截然不同的病理机制是皮肤肌炎,多肌炎和包容体肌炎的基础.
- 早期诊断和启动免疫疗法对于治疗皮肤肌炎和多肌炎至关重要.
- 新型免疫调节剂在耐火病例中表现有前途.
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