胸痛患者和正常冠状动脉患者的内皮功能障碍
A A Quyyumi1, R O Cannon, J A Panza
1Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Circulation
|December 1, 1992
概括
微血管内皮功能障碍可能导致冠状动脉扩张器储量减少,在患有胸痛和冠状动脉正常的患者中. 这种功能障碍与受损的内皮依赖扩张有关,有助于痛症状.
科学领域:
- 心血管医学 心血管医学
- 临床生理学 临床生理学
- 医学研究 医学研究
背景情况:
- 一些患有胸痛和冠状动脉正常的患者表现出血管扩张器反应的减少.
- 这种减少反应的潜在机制仍然不清楚.
- 这项研究调查了微血管内皮功能障碍作为潜在的原因.
研究的目的:
- 确定微血管内皮功能障碍是否有助于降低胸痛和正常心表冠状动脉的患者的血管扩展器储备.
- 评估内皮依赖和独立血管扩张之间的关系.
- 探索影响血管扩展反应的潜在因素.
主要方法:
- 研究了51名患有胸痛和正常冠状动脉的患者.
- 冠状动脉微血管功能的评估是使用快速心房节奏和冠状动脉内乙胆输液.
- 用酸 (nitroprusside) 测量了内皮独立的血管扩张.
主要成果:
- 通过乙胆和心房节奏诱导的冠状动脉抵抗变化之间发现了显著的相关性 (r = 0.68,p < 0.001).
- 在节奏调节期间扩张减少的患者也表现出与乙胆的内皮依赖扩张减少.
- 随着酸的血管扩张并没有显著不同,这表明缺陷不是由于光滑肌肉功能障碍.
结论:
- 微血管内皮功能障碍与患有胸痛患者的血管扩张减少有关,尽管心上冠状动脉正常.
- 这种内皮功能障碍可能是这组患者血管扩张器储量减少和胸痛症状的基础.
- 这些发现强调了评估非阻塞性冠状动脉疾病患者微血管功能的重要性.
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