心肌梗塞后心肌细胞增大,在狗中发生再输血
M Kambayashi1, T Miura, B H Oh
1Kyoto University Hospital, Japan.
Circulation
|December 11, 1992
概括
心肌梗塞的恢复涉及到存活的心脏细胞的细胞缩. 这项研究发现,心脏梗塞后壁和内心脏区域的细胞大小较大,这表明在再输液后的功能恢复中发挥了作用.
科学领域:
- 心血管生理学心血管生理学
- 进行心脏重塑.
- 心肌梗塞研究研究
背景情况:
- 心肌细胞增大在心肌梗塞 (MI) 和再输后收缩功能恢复中的作用尚不清楚.
- 研究缺血区的细胞变化对于了解MI后的长期心脏功能至关重要.
研究的目的:
- 检查心肌细胞增大在缺血区在心肌梗塞后区域收缩功能晚恢复的机制中心肌细胞增大可能的作用,然后再输血.
- 为了量化心肌细胞大小在心脏的不同区域的变化,心脏梗塞和再输后.
主要方法:
- 八只狗经历了冠状动脉封闭,然后再输血.
- 超声波仪测量了墙壁厚度和前面 (AT) 和后面 (PT) 墙壁的功能.
- 心肌细胞的截面区域被确定在心脏下部,中壁和心脏下部内脏区域三周后再输血.
主要成果:
- 后壁 (PT) 在封闭期间表现出动力障碍,但在再输液后恢复功能.
- 在心脏病发作后的PT壁中,心肌细胞的截面面积明显大于对照犬.
- 细胞缩观察到心脏内脏区域的两个心脏病发作和非心脏病发作的墙壁.
结论:
- 心肌梗塞之后的再注血导致了心脏病发作壁的显著细胞缩,特别是在心脏内脏区域.
- 在心脏梗塞区域中存活的肌肉细胞的过度缩小可能会导致区域收缩功能的晚期恢复.
- 这些发现强调了细胞重塑是缺血性损伤后心脏适应的关键组成部分.
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