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合成大麻素CT-3对慢性神经病痛的止痛作用:一项随机对照试验

Matthias Karst¹, Kahlid Salim, Sumner Burstein

¹Department of Anesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany. karst.matthias@mh-hannover.de

|October 2, 2003

概括

在人体试验中,CT-3是一种THC模拟物,有效降低了慢性神经病痛. 这种大麻素化合物表现出止痛特性,具有可控的副作用,如口腔干燥和疲劳.

科学领域:

药理学药理学是指药理学的学科.
神经学神经学
疼痛管理疼痛管理

背景情况:

1',1'dimethylheptyl-Delta8-tetrahydrocannabinol-11-oic acid (CT-3) 是THC-11-oic acid的一个强有力的模拟物.
在动物模型中,CT-3表现出抗氨酸和止痛作用,没有典型的大麻素副作用.
它显示出作为一种抗治疗性神经病痛的止痛药的潜力.

研究的目的:

为了评估CT-3在患有慢性神经病痛的人群中的止痛效果.
评估CT-3在该患者群体中的安全性.

主要方法:

进行了一项随机,安慰剂控制,双盲交叉试验.
患有慢性神经病痛的21名患者接受了CT-3或安慰剂,两次为期7天的治疗周期,一次为期1周的洗.
使用视觉模拟尺度 (VAS) 和口头评分尺度评估疼痛;通过生命体征,血液测试和不良事件报告监测安全性.

主要成果:

与安慰剂相比,CT-3显著降低了神经病痛,这是VAS得分 (P = .02) 所表明的.
不良反应,主要是过渡性口腔干燥和疲劳,在CT-3 (P = .02) 中更频繁地报告.
没有观察到生命体征,血液化学,心电图或认知测试的显著变化,除了对Trail-Making Test的转移效应.

结论:

在这项初步的人类研究中,CT-3在缓解慢性神经病痛方面表现出有效性.
该化合物一般耐受性良好,没有发现重大安全问题.

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