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含硫黄素的疫苗与自闭症之间的关联

Anders Hviid¹, Michael Stellfeld, Jan Wohlfahrt

¹Danish Epidemiology Science Centre, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. aii@ssi.dk

|October 2, 2003

概括

这项研究发现,含硫醇的疫苗和自闭症之间没有联系. 对疫苗中乙的研究表明,与儿童自闭症谱系障碍没有因果关系.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
儿科儿科儿科

背景情况:

疫苗中含有乙烯的防腐剂蒂默萨尔引起了人们对神经发育障碍的潜在联系的担忧.
化合物以其高剂量的毒和神经毒性作用而闻名.

研究的目的:

调查用含硫黄素的疫苗接种与自闭症和其他自闭症谱系障碍的发展之间的联系.
为了确定疫苗和自闭症谱系障碍之间的乙烯暴露之间是否存在剂量反应关系.

主要方法:

丹麦进行了一项以人口为基础的队列研究,包括1990年至1996年间出生的467,450名儿童.
用含硫醇疫苗接种的儿童与那些接种相同疫苗的无硫醇配方的儿童进行了比较.
评估了自闭症和自闭症谱系障碍,分析了乙烯的速率比率和剂量反应趋势.

主要成果:

接种了含硫黄素的疫苗的儿童和接种了无硫黄素的疫苗的儿童之间没有观察到自闭症或其他自闭症谱系障碍的风险显著差异.
该研究发现,没有证据表明接受的乙烯量与发展自闭症或其他自闭症谱系障碍的风险之间存在剂量反应关系.
自闭症的比率为0.85 (95% CI,0.60-1.20),其他自闭症谱系障碍的比率为1.12 (95% CI,0.88-1.43).

结论:

这些发现不支持儿童接种含硫醇疫苗和自闭症谱系障碍的发展之间的因果关系.
这项研究有助于了解疫苗安全性和神经发育结果.

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