甲型肝炎复发疫苗接种:有没有必要?
P Van Damme1, J Banatvala, O Fay
1Centre for the Evaluation of Vaccination, WHO Collaborating Centre for Control and Prevention of Viral Hepatitis, Unit of Epidemiology and Social Medicine, University of Antwerp, 2610 , Antwerp, Belgium. pierre.vandamme@ua.ac.be
Lancet (London, England)
|October 3, 2003
概括
甲型肝炎疫苗提供长期保护,在健康人群中持续超过10年. 目前的证据表明,在这个人群接受完整的初级疫苗接种后,再注射是不必要的.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 全球范围内,甲型肝炎是疫苗可预防的流行性传染病.
- 自1992年以来可用的甲型肝炎疫苗提供了长期免疫力,但对持续时间和增强剂需求缺乏共识.
- 补充疫苗接种政策各不相同,通常取决于制造商或国家当局的指导方针.
研究的目的:
- 审查甲型肝炎病毒 (HAV) 疫苗所赋予的长期免疫性和保护.
- 评估未来在不同人群中进行HAV强剂疫苗接种的必要性.
主要方法:
- 一个由国际专家组成的小组于2002年6月召开会议.
- 审查了关于长期免疫性和对HAV疫苗的保护的现有数据.
主要成果:
- 在初级疫苗接种后的健康人群中,保护性抗体水平持续超过10年.
- 免疫记忆提供了超出可检测抗体持续时间的保护.
- 没有证据支持在完成初级疫苗接种后,在健康人群中需要HAV强剂疫苗接种.
结论:
- 对于已经完成初级疫苗接种的健康人群,A型肝炎的强制性疫苗接种并不适用.
- 需要进一步的研究来确定是否可以在特定的患者群体中省略强剂.
相关概念视频
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