阿波利波蛋白E基因与性膜心脏病之间的关联
Gian M Novaro1, Ravish Sachar, Gregory L Pearce
1Department of Cardiology, Desk A-23, The Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, Fla 33331, USA. novarog@ccf.org
阿波利波蛋白E4 (apoE4) 基因基因与大动脉狭窄 (AS) 风险有关,但与中枢环状化 (MAC) 无关. 这一发现扩大了apoE4的范围.
科学领域:
- 心血管遗传学 心血管遗传学
- 分子心脏病学分子心脏病学
- 膜心脏疾病研究研究
背景情况:
- Apolipoprotein E (apoE) 的等位基因,特别是apoE4,是冠状动脉心脏病的确立危险因素.
- 冠状动脉疾病和性膜心脏病 (大动脉狭窄症[AS]和环化[MAC]) 之间存在组织学上的相似之处.
研究的目的:
- 调查阿波利波蛋白E (apoE) 基因与状膜病变,特别是AS和MAC的发展之间的关联.
主要方法:
- 对802名接受过胸前心声扫描的患者进行了后勤回归分析.
- 基因型分布和apoE4等位基因的患病率在AS和MAC患者和没有AS和MAC患者之间进行了比较.
- 多变量分析根据年龄,性别,LDL胆固醇和冠状动脉疾病进行调整.
主要成果:
- 在患有或没有甲骨环状化 (MAC) 的患者之间,没有发现apoE基因型分布或apoE4患病率的显著差异.
- 在患有大动脉狭窄症 (AS) 的患者中观察到apoE基因型分布的显著差异 (P=0.03).
- 在对其他风险因素进行调整后,apoE4等位基因是AS (OR,1.94;P=0.046) 的显著独立预测因子.
结论:
- 阿波利波蛋白E4 (apoE4) 基因基因与形大动脉狭窄症 (AS) 的风险增加有关.
- 这些发现表明,apoE4等位基因的作用超出了动脉样硬化和阿尔茨海默病的范围,包括性AS.
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