相关实验视频
Updated: Jul 5, 2026

10:09
Operation of the Collaborative Composite Manufacturing (CCM) System
Published on: October 1, 2019
微信J25具有有线侧链到脊柱环结构,而不是从头到尾的循环脊柱
K Johan Rosengren1, Richard J Clark, Norelle L Daly
1Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia.
Journal of the American Chemical Society
|October 9, 2003
概括
微信J25是一种强大的抗菌,没有头到尾的循环结构. 相反,它具有独特的环状结构,解释了其非凡的稳定性和抗菌活性对抗阴性细菌.
科学领域:
- 生物化学 生物化学
- 结构生物学 结构生物学
- 抗微生物是一种抗菌.
背景情况:
- 微信J25是一种21氨基酸,具有强大的抗菌活性,可以对抗阴性细菌.
- 之前的研究提出了从头到尾的循环结构,有助于其热稳定性.
- 这种稳定性对于缺乏二硫化物键的来说是值得注意的.
研究的目的:
- 为了阐明Microcin J25精确的三维结构.
- 确定其非凡的热稳定性和强大的抗菌活性的结构基础.
- 重新评估之前提出的头到尾循环模型.
主要方法:
- 核磁共振 (NMR) 光谱法被用来推断出的3D结构.
- 使用生物物理技术来评估热稳定性和结构完整性.
- 用热解进行了酶性消化,以测试结构强度.
主要成果:
- 这项研究表明,Microcin J25缺乏从头到尾的循环结构.
- 一个新的侧链到脊柱循环 (Glu8到N端) 形成了一个嵌入式环,由C端尾部线,创建一个环状特征.
- 环周边的两个芳香残留物防止滑动,即使在热溶消化后也保持结构完整性.
结论:
- 新发现的状结构解释了Microcin J25的特殊稳定性和强大的抗菌活性.
- 这种修订后的结构模型协调了以前的NMR和生物物理数据.
- 独特的结构代表了稳定性和功能的新机制.
相关概念视频
The Spinal Cord
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
Vertebral Column: Regions and Curvature
The vertebral column or spine is a flexible column that supports the head, neck, and body and allows for their movements. It also protects the spinal cord.
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form the...
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form the...
General Structure of a Vertebra
A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous column.
Structural Joints: Cartilaginous Joints
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary or...
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary or...
Spinal Cord: Cross-sectional Anatomy
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
Spinal Cord
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.

