脑和单胎婴儿的子宫内生长:欧洲合作研究
Stephen Jarvis1, Svetlana V Glinianaia, Maria-Giulia Torrioli
1Institute of Child Health, University of Newcastle, UK.
Lancet (London, England)
|October 11, 2003
概括
对于怀孕年龄来说出生体重非常低或非常高的婴儿,脑风险最高. 针对妊娠年龄的最佳出生体重与最低的脑风险有关.
科学领域:
- 新生儿神经学 新生儿神经学
- 发育儿科 发育儿科
- 公共卫生 公共卫生
背景情况:
- 大脑麻 (CP) 经常在孕期婴儿中观察到,他们的出生体重低于妊娠年龄.
- 此前对这种关联的研究受限于小样本大小和不一致的Z分数计算方法.
研究的目的:
- 为了调查出生体重与妊娠年龄之间的联系和脑的风险.
- 分析来自多个欧洲出生登记册的大量数据集.
主要方法:
- 分析了来自10个欧洲登记处 (1976-1990) 诊断为脑的4503名单身儿童的数据.
- 婴儿体重和妊娠年龄与已建立的胎儿生长和体重与妊娠年龄的参考标准进行了比较.
主要成果:
- 妊娠32-42周之间的婴儿出生体重低于妊娠年龄的第10百分位,患脑的风险高4-6倍.
- 增加出生体重 (97个百分点以上) 也呈现出显著的,虽然较小的,增加的风险 (1.6-3.1倍).
- 最低的风险观察到的是出生体重大约比妊娠年龄平均值高出1个标准偏差的婴儿.
结论:
- 脑性麻的风险,类似于围产期死亡率,对于体重高于平均水平的婴儿来说是最低的.
- 对于妊娠年龄来说,显著的低出生体重和显著的高出生体重都与增加脑风险有关.
- 胎儿生长偏差和脑之间的因果关系需要进一步调查.
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