埃奇诺坎丁是一种抗真菌药物
1Education and Research Centre, Wythenshawe Hospital, Southmoor Road, M23 9LT, Manchester, UK. ddenning@man.ac.uk
Lancet (London, England)
|October 11, 2003
概括
埃奇诺坎丁是抑制真菌细胞壁合成的抗真菌药物. 与传统的抗真菌药物相比,它们显示出有前途的有效治疗方法,副作用较少.
科学领域:
- 药理学 药理学是指药理学的学科.
- 菌类学 菌类学是指菌类学.
背景情况:
- 埃奇诺坎丁是脂类抗真菌药物,其向的是β - 1,3) - 葡萄糖合成.
- 这种机制会损害真菌细胞壁,导致杀菌或杀菌效应.
研究的目的:
- 审查类的特性和临床应用.
- 将它们的疗效和安全性与现有的抗真菌疗法进行比较.
主要方法:
- 在体外和体内研究的文献综述.
- 对卡斯波金和米卡金的临床试验数据的分析.
- 对药理动力学和药理动力学性质的评估.
主要成果:
- 埃奇诺坎丁可以有效地对抗Candida spp. 和 Aspergillus spp. 这种植物. 但不包括Zygomycetes,Cryptococcus neoformans,或Fusarium spp. 这些类型.
- 卡斯波金在耐火性侵入性阿斯伯吉洛症中显示出40%的应答率.
- 研究表明, echinocandins 的疗效与安福特里辛B 的疗效相当,安全性更好.
结论:
- 埃奇诺坎丁具有良好的安全性,适合静脉注射.
- 有限的药物相互作用和每天一次的剂量提高了它们的临床效用.
- 与其他抗真菌药物结合治疗的潜力,特别是在侵袭性阿斯伯吉洛症.
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