人类心力衰竭中/交换功能的动态调节
Christopher R Weber1, Valentino Piacentino, Steven R Houser
1Department of Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Ill 60153, USA.
Circulation
|October 15, 2003
概括
在人类心力衰竭中,膜Na/Ca交换 (NCX) 转向有利于进入. 这种改变的NCX功能有助于异常的处理和腹功能障碍.
科学领域:
- 心脏病学 心脏病学
- 细胞生理学 细胞生理学
- 生物物理学的生物物理.
背景情况:
- 膜Na/Ca交换 (NCX) 对于调节心脏和收缩性至关重要.
- NCX功能受到细胞内 ([Ca]i),细胞内 ([Na]i) 和膜潜力 (Em) 的影响.
- 这些因素在人类心力衰竭 (HF) 中发生变化,可能会改变NCX功能并导致异常的调节.
研究的目的:
- 为了研究导致NCX功能在失败 (F) 和非失败 (NF) 人类腹腔肌细胞之间的差异的细胞机制.
- 确定[Ca]i,[Na]i和动作潜力的变化如何影响高频中NCX介导的运输.
主要方法:
- 从人类失败和非失败的心脏中评估心室肌细胞中的NCX功能.
- 通过[Ca]i.i.测量NCX的全激活.
- 在动力潜力 (AP) 和使用尾流测量过程中推断的局部亚膜[Ca]i ([Ca]sm) 和过渡物.
- 在AP期间分析了NCX介导的运输方向.
主要成果:
- 通过[Ca]i对NCX的性激活在F和NF肌细胞中是相似的.
- 在NF肌细胞中,NCX主要在AP期间挤出.
- 在F肌细胞中,由于减少[Ca]sm,延长AP持续时间和增加[Na]i,NCX介导的运输转向流入.
结论:
- 在HF中改变的NCX功能有利于的进入.
- 通过NCX介导的输入可能部分抵消由减少的质网膜储量引起的缩功能障碍.
- 这种NCX活动的转变可能会导致慢慢的过时衰变和高频率的腹功能障碍.
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