血液中氧气水平依赖的磁共振成像在患有压力诱导的胸痛的患者
Matthias G Friedrich1, Thoralf Niendorf, Jeanette Schulz-Menger
1Helios-Klinikum Berlin, Franz-Volhard-Klinik, Kardiologie Charité Campus Berlin-Buch, Medizinische Fakultaet der Humboldt-Universitaet Berlin, Germany. friedrich@fvk-berlin.de
Circulation
|October 15, 2003
概括
血氧水平依赖 (BOLD) 的MRI可以检测怀疑冠状动脉疾病的患者心肌缺血. 这种技术对识别严重的冠状动脉狭窄症,导致压力诱导的胸痛有前途.
科学领域:
- 心血管成像 - 心血管成像
- 医学诊断 医学诊断 医学诊断
- 身体生理学 身体生理学
背景情况:
- 血液氧气水平依赖 (BOLD) 磁共振成像 (MRI) 评估组织氧化.
- 大胆的MRI可能有助于检测怀疑冠状动脉疾病的患者心肌缺血.
研究的目的:
- 为了评估腺诱导的BOLDMRI在识别心肌缺血的实用性.
- 为了将BOLDMRI发现与冠状动脉血管学和SPECT在患有压力诱导性心痛的患者中相关联.
主要方法:
- 一个T2*敏感的回声平面成像序列被用于25名患有压力诱发性心痛的患者.
- BOLD MRI 在腺注射之前和期间进行.
- 结果与定量血管造影和腺单光子发射计算机断层扫描 (SPECT) 进行了比较.
主要成果:
- 在腺时,心肌段与冠状动脉狭窄症>75%的平均信号强度下降被观察到.
- 大胆的MRI显示88%的灵敏度和47%的特异性来分类严重的狭窄症.
- 与SPECT的相关性显示出相当大的变化.
结论:
- 氨酸BOLDMRI有效地检测了与严重冠状动脉狭窄症相关的部分心肌缺血.
- 进一步改善空间覆盖和图像质量可以提高其诊断潜力.
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