阿尔多斯特调节血管反应性:通过酸氨基醇3-酶依赖的氧化合成酶激活调节的短期效应
Selina L Liu1, Saskia Schmuck, Jozef Z Chorazcyzewski
1Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.
Circulation
|October 15, 2003
概括
阿尔多素迅速影响血管功能. 它放松了内皮完好无损的血管,但收缩了没有的血管,影响了血管抵抗和心血管疾病.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
背景情况:
- 新出现的证据表明,阿尔多的快速,非基因组效应.
- 阿尔多素对血管反应的直接影响需要进一步调查.
研究的目的:
- 为了研究阿尔多斯特对老鼠大动脉环血管反应的直接影响.
- 为了检查内皮和血管光滑肌细胞中阿尔多的细胞反应.
主要方法:
- 利用老鼠大动脉环段 (内皮完好和脱皮) 来评估血管反应性.
- 在内皮细胞中研究了细胞信号通路,包括氧化合成酶活性和激酶激活.
主要成果:
- 阿尔多斯特减弱的烯诱导的缩在内皮完好无损的环.
- 阿尔多激素增强了内皮脱皮血管中的血管收缩.
- 在内皮细胞中,阿尔多斯特增加了氧化合成酶的活性,并通过PI3K激活ERK1/2和p70S6激酶.
结论:
- 阿尔多斯特对血管内皮和光滑肌肉细胞产生新的,快速的影响.
- 这些快速的作用可能在调节外周血管抵抗方面发挥作用.
- 在内皮功能障碍中改变的阿尔多素反应可能会导致心血管疾病的发病.
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