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在早期动脉样硬化中血管生成的分子成像使用向alpha(v) beta3-整合素的纳米粒子

Patrick M Winter¹, Anne M Morawski, Shelton D Caruthers

¹Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Washington University School of Medicine, St Louis, Mo 63110, USA.

|October 15, 2003

概括

这项研究表明,目标纳米颗粒可以使用MRI检测动脉样硬化中的新血管生长. 这种分子成像可能有助于跟踪疾病的进展和治疗的有效性.

科学领域:

心血管研究研究心血管研究
分子成像学分子成像学
纳米技术纳米技术

背景情况:

血管新生,或新的血管形成,对于动脉样硬化斑块的发展和破裂至关重要.
目前的诊断方法无法检测早期的分子或细胞事件,导致斑块生长和不稳定.

研究的目的:

为了研究alpha(v) beta3-integrin向性,偏磁性纳米颗粒用于检测动脉样硬化中的血管生成.
评估这种分子成像方法在监测动脉样硬化进展和治疗反应方面的潜力.

主要方法:

在子中诱导动脉样硬化是通过食1%胆固醇饮食.
通过静脉注射的alpha(v) beta3-Integrin向的,偏磁纳米颗粒被使用.
磁共振成像 (MRI) 用于检测纳米粒子积累和新血管.

主要成果:

磁力共振成像检测到,在接受向纳米颗粒的子中,腹腔大动脉壁信号增强了47+/-5%,表明血管生成增加.
竞争性阻断实验证实了纳米粒子向alpha(v) beta3-integrin的特异性.
组织学证实了动脉样硬化性大动脉中血管性和新极端扩散的增加.

结论:

使用向纳米颗粒的分子成像为评估动脉样硬化负担和演变提供了一种新的方法.
这种方法可以实现个性化监测患者对抗动脉样硬化疗法的反应.

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