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肺衰竭对生长中的猪心脏发育中的双心脏功能的影响

Titus Kuehne¹, Maythem Saeed, Kelly Gleason

¹Division of Pediatric Cardiology and Department of Radiology, University of California San Francisco, San Francisco, Calif 94143, USA.

|October 15, 2003

概括

年轻猪的慢性肺衰竭改变了心脏功能,影响了右心室和左心室. 这项研究揭示了心缩和心肌收缩性能的变化.

科学领域:

心血管研究研究心血管研究
儿童心脏病学儿童心脏病学
肺高血压是什么意思肺高血压

背景情况:

慢性肺衰竭 (PI) 可以影响心脏功能.
了解它对发育中的心脏的影响至关重要.

研究的目的:

为了确定慢性肺衰竭 (PI) 对年轻生长猪右 (RV) 和左 (LV) 室功能的影响.
为了评估心缩和心肌收缩功能的变化,以及心肌收缩性.

主要方法:

通过跨导管支架安置诱导的肺衰竭.
磁力共振成像量化了PI和心室体积.
导电导管技术评估了收缩性和合规性.

主要成果:

3个月后,PI组显示出显著的肺吐分数 (49.2+/-5.9%).
RV心脏功能储备受到限制;透缩功能保持;收缩能力改变.
LV心脏功能储备有限;遵守性降低;收缩性保持.

结论:

年轻猪的慢性PI改变了双心室缩功能.
影响了右心室心肌收缩率和左心室透静性能.

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