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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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相关实验视频

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Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge
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冠状动脉热稀释和多普勒速度的比较,用于评估冠状动脉流量储备.

William F Fearon1, H M Omar Farouque, Leora B Balsam

  • 1Division of Cardiovascular Medicine, Stanford University Medical Center, H3554, 300 Pasteur Dr, Stanford, Calif 94305, USA. wfearon@stanford.edu

Circulation
|October 22, 2003
PubMed
概括

新热稀释冠状动脉流量储量 (CFRthermo) 与绝对流量衍生的CFR (CFRflow) 密切相关,性能优于多普勒衍生的CFR (CFRDoppler). 这表明CFRthermo可能为侵袭性冠状动脉流量储备评估提供可靠的替代方案.

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科学领域:

  • 心血管生理学心血管生理学
  • 干预心脏病学 干预心脏病学
  • 诊断技术 诊断技术 诊断技术

背景情况:

  • 冠状动脉流量储备 (CFR) 评估对于诊断冠状动脉疾病至关重要.
  • 热稀释冠状动脉流量储备 (CFRthermo) 是一种使用压力电线的新兴侵入性技术.
  • 与已建立的方法相比,CFRthermo的临床实用性正在研究中.

研究的目的:

  • 评估热稀释冠状动脉流量储备 (CFRthermo) 和绝对流量衍生的CFR (CFRflow) 之间的相关性.
  • 为了比较CFRthermo与多普勒导线衍生的CFR (CFRDoppler) 的准确性,与参考标准进行比较.

主要方法:

  • 使用一个开放胸部的猪模型,同时使用热稀释,多普勒和外部流量探针 (CFRflow) 来测量CFR.
  • 在正常和狭窄的左前下降动脉 (LAD) 中评估CFR,并在诱导微血管疾病后.
  • 在所有测量结果中,给予冠状动脉内巴巴维林以达到高血压.

主要成果:

  • CFRthermo与参考标准CFR流量 (r=0.85,P<0.001) 显示出强烈的相关性.
  • CFR多普勒显示,与CFR流动的相关性较弱 (r=0.72,P<0.001).
  • 布兰德-阿尔特曼分析表明,CFRthermo和CFRflow之间更接近一致.

结论:

  • 热稀释冠状动脉流量储备 (CFRthermo) 与绝对流量衍生的CFR (CFRflow) 相比,与多普勒衍生的CFR (CFRDoppler) 相比,具有更好的相关性.
  • CFRthermo是一个可靠的侵入性方法,用于评估冠状动脉流量储备.