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通过IFN-马诱导的LRG-47进行结核病的免疫控制

John D MacMicking1, Gregory A Taylor, John D McKinney

  • 1Laboratory of Infection Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. macmicj@mail.rockefeller.edu

Science (New York, N.Y.)
|October 25, 2003
PubMed
概括

干扰素- (IFN-) 激活巨细胞以对抗结核病 (Mtb). 一种新型蛋白质,LRG-47,通过帮助体成熟,独立于氧化合成酶2 (NOS2) 来独立地保护Mtb.

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...