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相关概念视频

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Fascicle Arrangement in Skeletal Muscles01:25

Fascicle Arrangement in Skeletal Muscles

Fascicles are bundles of muscle fibers in a skeletal muscle. Muscle fascicle arrangement is directly associated with the power and range of motion of various muscles. The configuration of these fascicles can vary, leading to different functional outcomes.
The four primary types of muscle based on fascicle arrangement are:

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相关实验视频

Updated: Jul 8, 2026

A New Clarification Method to Visualize Biliary Degeneration During Liver Metamorphosis in Sea Lamprey (Petromyzon marinus)
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A New Clarification Method to Visualize Biliary Degeneration During Liver Metamorphosis in Sea Lamprey (Petromyzon marinus)

Published on: June 6, 2014

在斑马鱼中,肠循环形态发生的细胞框架.

Sally Horne-Badovinac1, Michael Rebagliati, Didier Y R Stainier

  • 1Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, University of California, San Francisco, CA 94143, USA.

Science (New York, N.Y.)
|October 25, 2003
PubMed
概括
此摘要是机器生成的。

斑马鱼的肠道循环由不对称的侧板介质体迁移引起,由节点信号驱动. 破坏这种迁移或上皮结构会抑制肠道不对称性,揭示器官横向性的细胞基础.

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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

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Isolation and 3D Collagen Sandwich Culture of Primary Mouse Hepatocytes to Study the Role of Cytoskeleton in Bile Canalicular Formation In Vitro
10:12

Isolation and 3D Collagen Sandwich Culture of Primary Mouse Hepatocytes to Study the Role of Cytoskeleton in Bile Canalicular Formation In Vitro

Published on: December 20, 2019

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Last Updated: Jul 8, 2026

A New Clarification Method to Visualize Biliary Degeneration During Liver Metamorphosis in Sea Lamprey (Petromyzon marinus)
07:03

A New Clarification Method to Visualize Biliary Degeneration During Liver Metamorphosis in Sea Lamprey (Petromyzon marinus)

Published on: June 6, 2014

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Isolation and 3D Collagen Sandwich Culture of Primary Mouse Hepatocytes to Study the Role of Cytoskeleton in Bile Canalicular Formation In Vitro
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科学领域:

  • 发育生物学是发展生物学.
  • 有机体的产生.
  • 斑马鱼模型系统模型系统

背景情况:

  • 脊椎动物的器官定位通常是不对称的,但潜在的细胞机制仍然不清楚.
  • 已知左右基因表达会影响器官不对称性,但下游细胞事件的理解很差.

研究的目的:

  • 为了研究斑马鱼肠道循环和不对称的器官定位的细胞基础.
  • 为了确定侧板介质体 (LPM) 迁移在肠道侧向性中的作用.
  • 为了阐明在有机发生过程中不对称的组织运动的遗传调节.

主要方法:

  • 使用斑马鱼作为模型生物来研究肠道循环.
  • 研究了突变破坏LPM上皮质结构对肠道不对称性的影响.
  • 进行了内皮剥离实验,以评估LPM在迁移中的自主作用.
  • 操纵节点信号,观察其对LPM迁移和肠循环模式的影响.

主要成果:

  • 斑马鱼的肠道循环是由相邻的侧板介质体 (LPM) 的不对称迁移驱动的.
  • 在LPM上皮质完整性的破坏阻碍了不对称的迁移,并因此抑制肠道循环.
  • LPM可以自主产生用于肠道移位的力量,独立于内皮.
  • 减少左侧节点活动导致随机的LPM迁移和肠循环.

结论:

  • 不对称的LPM迁移是一个关键的细胞机制,是斑马鱼肠道循环的基础.
  • 皮质结构的LPM对于指导细胞迁移和器官不对称至关重要.
  • 节点信号在调节LPM的方向迁移,建立器官横向性方面发挥着至关重要的作用.