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人类心表脂肪组织是炎症媒介的来源
Tomasz Mazurek1, LiFeng Zhang, Andrew Zalewski
1Department of Surgery, Thomas Jefferson University, Suite 623, 1025 Walnut St, Philadelphia, Pa 19107, USA.
Circulation
|October 29, 2003
概括
围绕心脏的心脂肪组织释放更多的炎症调解物,比如冠状动脉疾病患者的皮下脂肪更容易释放interleukin-6和单细胞化疗蛋白-1.
科学领域:
- 心血管科学 心血管科学
- 炎症研究 炎症研究
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 来自血管和血管外组织的炎症媒介驱动冠状动脉病变的发展.
- 脂肪组织可能充当内分泌器官,增加炎症和心血管疾病风险.
- 心脂肪组织 (EAT) 在关键冠状动脉疾病 (CAD) 炎症中的作用尚不清楚.
研究的目的:
- 在危急的CAD患者中,比较心上表层与皮下脂肪组织中的炎症媒介表达.
- 调查血生物标志物是否反映了局部脂肪组织炎症.
主要方法:
- 从42名CABG手术患者中采集了配对的上心脏和皮下脂肪组织.
- 分析了interleukin-1beta,interleukin-6,单细胞化疗蛋白-1和瘤死亡因子-alpha的mRNA和蛋白质水平.
- 使用了TaqMan实时RT-PCR,ELISA和DNA微阵列混合.
主要成果:
- 心脂肪组织显示了关键炎症媒介的mRNA和蛋白质水平显著更高.
- 在EAT中,炎症独立于临床因素和血生物标志物度.
- 基因表达分析和组织学证实了广泛的炎症反应和细胞透在EAT.
结论:
- 心脂肪组织是高风险心脏病患者炎症媒介的重要来源.
- 血炎症生物标志物可能不能准确地代表局部组织炎症.
- 目前的治疗方法无法解决心表脂肪组织中的局部炎症信号.
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