在心力衰竭中运动诱导的肺
Piergiuseppe Agostoni1, Gaia Cattadori, Michele Bianchi
1Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Università di Milano, Via Parea 4, 20138 Milan, Italy. Piergiuseppe.agostoni@CCFM.it
Circulation
|October 29, 2003
概括
在心力衰竭 (HF) 患者中,运动降低了膜-毛囊膜电导率 (Dm),这表明潜在的肺. 这种效应在有周期性呼吸的HF患者中最为明显.
科学领域:
- 肺部生理学 肺部生理学
- 进行心肺运动测试.
- 呼吸系统药物 呼吸系统药物
背景情况:
- 心力衰竭 (HF) 患者可能会随着运动而患上肺,这是由于肺毛细血管的水静压增加.
- 如果运动后出现肺水腫,预计膜-毛囊膜导电性 (Dm) 会降低.
研究的目的:
- 为了研究HF患者在运动后Dm的变化.
- 要确定运动诱导的肺是否会影响Dm.
主要方法:
- 测量Dm,一氧化碳扩散容量 (DLco) 和毛细血管血液体积 (Vc) 在休息状态和运动后的2分钟和60分钟.
- 在HF患者和对照人群中使用了Roughton-Forster技术.
- 对HF患者的Dm变化进行了比较,这些患者有周期性呼吸,严重的HF,中度的HF和健康的对照.
主要成果:
- 在HF患者 (定期呼吸,严重和中度HF) 中,Dm在运动后2分钟显著下降,但在对照组中没有.
- 在所有组中,Vc在运动后增加,仅在定期呼吸组中,在60分钟内仍然升高.
- 在运动后2分钟,HF组的Dm/Vc下降,只有在定期呼吸组,Dm和Dm/Vc在60分钟后仍然很低.
结论:
- 运动导致HF患者的膜-毛囊膜导电率下降,这表明气体交换受损,可能是由于肺.
- Dm的减少在经历周期性呼吸的HF患者中最为显著,在不那么严重的HF患者中不那么明显.
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