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Cell-mediated Immune Responses01:40

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
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对阿尔茨海默病的免疫治疗方法.

Alon Monsonego1, Howard L Weiner

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. amonsonego@rics.bwh.harvard.edu

Science (New York, N.Y.)
|November 1, 2003
PubMed
概括

在阿尔茨海默氏症等神经退行性疾病中经常被忽视的免疫系统显示出潜在的治疗益处. 针对免疫反应的免疫疗法为治疗这些疾病提供了新的途径,包括对微质细胞的影响.

科学领域:

  • 神经免疫学 神经免疫学
  • 神经退行性疾病 神经退行性疾病
  • 阿尔茨海默病的治疗方法 治疗方法

背景情况:

  • 包括阿尔茨海默病在内的神经退行性疾病越来越多地被认为涉及免疫系统相互作用.
  • 免疫系统可以对中枢神经系统产生有害和有益的影响.
  • 微质激活是神经退行性疾病治疗策略中的关键因素.

研究的目的:

  • 探索免疫系统在神经退行性疾病中的作用,重点关注阿尔茨海默病.
  • 审查阿尔茨海默病的免疫治疗方法及其对免疫反应的影响.
  • 在神经退行性疾病治疗的背景下,讨论免疫治疗对微质激活的影响.

主要方法:

  • 关于阿尔茨海默病免疫治疗策略的现有文献的审查.
  • 在动物模型和人体试验中分析了涉及幽默和细胞免疫反应的研究.
  • 检查这些免疫疗法对微质细胞激活的影响.

主要成果:

  • 对阿尔茨海默病的免疫疗法在人类试验中产生了积极和消极的结果.
  • 细胞免疫反应,特别是T细胞活动,在中枢神经系统损伤时可以有益或有害.
  • 免疫治疗方法调节微质激活,这是疾病管理的关键组成部分.

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Published on: March 14, 2011

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结论:

  • 免疫系统是一个有希望的,虽然复杂的,针对神经退行性疾病的新疗法的目标.
  • 进一步研究特定的免疫反应,如T细胞亚型和微质细胞调节,至关重要.
  • 免疫疗法为治疗阿尔茨海默病和其他神经退行性疾病提供了潜在的新前沿.