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在心血管疾病中使用内啡素受体阻塞剂

Stuart Rich¹, Vallerie V McLaughlin

¹Rush Heart Institute Center for Pulmonary Heart Disease, Rush Medical College, Chicago, Ill, USA. Stuart_Rich@rush.edu

|November 5, 2003

概括

内甲素 (ET) 受体对抗剂在肺高血压方面表现有前途,改善运动能力. 然而,结合性心力衰竭的结果令人失望,需要进一步的研究.

科学领域:

心血管药理学心血管药理学
内分泌学在内分泌学.

背景情况:

内皮素 (ET) 系统,特别是ET-1,在心血管功能中起着重要作用.
ET-1的强烈血管收缩和菌效应将其与各种心血管疾病联系起来.

研究的目的:

评估ET受体对抗剂在心血管疾病中的疗效.
探索阻断ET受体的治疗潜力.

主要方法:

对ET受体抗剂的研究综述,包括博森坦 (非选择性) 和西塔克森坦 (选择性ET A).
对肺动脉高血压和充血性心力衰竭的临床结果的分析.

主要成果:

ET受体对抗作用对肺高血压有益,改善运动能力和临床结果.
博森坦和西塔克森坦在肺动脉高血压中表现出积极的影响.
ET受体对抗剂在充血性心力衰竭中产生了令人失望的结果,较大的试验是中性的.

结论:

ET受体对抗剂对肺高血压有效.
它们在充血性心力衰竭中的有用性是可疑的.
对ET受体抗剂的进一步研究,可能在组合疗法中,对于其他疾病是必要的.

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