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Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
姿势对血液和眼内压力的影响 多重系统缩,纯自主性衰竭和巴罗反射失效
Chasidy D Singleton1, David Robertson, Daniel W Byrne
1Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tenn,. USA.
Circulation
|November 5, 2003
概括
患有自主功能障碍的患者在改变位置时,平均动脉压 (MAP) 和眼内压 (IOP) 都会显著下降. 这表明自主神经系统在调节内血压方面发挥着关键作用.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 心血管生理学心血管生理学
背景情况:
- 眼内压力 (IOP) 调节可能涉及全身血管控制.
- 自主功能障碍可能会影响生理调节.
- 了解全身和眼睛压力之间的联系至关重要.
研究的目的:
- 在患有自主功能障碍的患者中研究血压和眼内压力之间的相关性.
- 为了确定自主功能障碍是否会改变系统和眼睛压力之间的关系.
主要方法:
- 比较静脉压力,血压 (静脉压,静脉压,MAP) 和心率在仰卧,坐着和站着的位置.
- 包括11名患有多重系统缩,纯自主性衰竭或巴罗反射功能衰竭的患者,以及年龄/性别匹配的对照.
- 使用一般线性模型重复测量ANOVA分析数据.
主要成果:
- 自主功能障碍患者的MAP (31 mm Hg) 和IOP (6 mm Hg) 从卧卧到站立显著下降 (P<0.001).
- 控制器显示MAP (+4 mm Hg) 和IOP (1 mm Hg) 在位置变化时的变化很小.
- 在姿势变化期间,在患者和对照组之间没有观察到显著的心率变化 (P=0.648).
结论:
- 在患有自主功能障碍的患者中,平均动脉压 (MAP) 的显著下降与眼内压 (IOP) 的显著下降相关.
- 这些发现表明自主神经系统在调节IOP方面发挥着重要作用,可能是通过全身血压的影响.
关键词:
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