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选择性环氧化原酶-2 抑制剂对盐引起的高血压中内皮功能的影响
Matthias Hermann1, Giovanni Camici, Aisha Fratton
1Cardiology, Cardiovascular Center, University Hospital Zürich, the Institute of Physiology, University of Zürich-Irchel, Germany.
Circulation
|November 5, 2003
概括
切莱科西布改善了内皮功能障碍,减少了因盐引起的高血压的氧化应激,与罗菲科西布或迪克洛芬雅克不同. 这突显了COX-2抑制剂之间心血管安全效应的差异.
科学领域:
- 心血管药理学心血管药理学
- 高血压研究 高血压研究
- 内皮功能研究 研究内皮功能研究
背景情况:
- 选择性循环氧化酶 (COX) -2 抑制剂 (coxibs) 的心血管安全性仍然存在争议.
- 内皮功能障碍是心血管疾病的关键代用标记.
- 盐引起的高血压是研究心血管风险的相关模型.
研究的目的:
- 为了比较两种不同的coxibs (rofecoxib,celecoxib) 和传统的NSAID (diclofenac) 对内皮功能障碍的影响.
- 在盐引起的高血压模型中研究这些效应.
- 评估对氧化应激标志物的影响.
主要方法:
- 对盐敏感 (DS) 和耐盐 (DR) 的达尔大鼠被食高饮食.
- 狄克洛菲纳克,罗菲科克西布或塞莱科克西布从第35天到第56天进行了治疗.
- 通过对大动脉环中的乙胆诱导的放松来评估内皮功能.
- 测量了氧化合成酶抑制和8-异质水平,以评估NO释放和氧化应激.
主要成果:
- 切莱科西布,但不是罗菲科西布或迪克洛芬雅克,在高血压大鼠中改善了NO介导的内皮依赖放松.
- 塞莱科克西布使基底氧化 (NO) 释放正常化,而其他治疗方法没有.
- 塞莱科克西布显著降低了8-异质水平的升高,这表明氧化应激减少.
结论:
- 切莱科克西布在盐引起的高血压中对内皮功能障碍和氧化应激产生有益影响.
- 罗菲科西布和迪克洛芬雅克没有表现出类似的改善,这表明coxibs之间存在不同的心血管安全概况.
- 这些发现强调了考虑可克西布类药物特异性影响的重要性.
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