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Updated: Jun 23, 2026

Techniques to Induce and Quantify Cellular Senescence
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在端粒启动的衰老中,DNA损伤检查点反应

Fabrizio d'Adda di Fagagna1, Philip M Reaper, Lorena Clay-Farrace

  • 1[1] The Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK [2] Present address: IFOM-FIRC Institute of Molecular Oncology, via Adamello 16, 20139 Milan, Italy.

Nature
|November 11, 2003
PubMed
概括

细胞衰老,即增殖潜力的丧失,与染色体末端 (端粒) 的DNA损伤有关. 功能障碍的端粒激活DNA损伤检查点,阻止细胞分裂. 这项研究揭示了端粒功能障碍是衰老的关键驱动因素.

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