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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

367
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
367

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改善抑郁症护理对关节炎老年人疼痛和功能结果的影响:随机对照试验.

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  • 1Center for Health Studies, Group Health Cooperative, Seattle, Wash 98101, USA. lin.e@ghc.org

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对患有关节炎的老年人的改善抑郁症护理显著减少了疼痛,改善了日常功能和生活质量. 这种协作治疗方法对心理和身体健康结果都有好处.

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科学领域:

  • 老年医学 老年医学
  • 精神病学是一个精神病学.
  • 类风湿病学 类风湿病学
  • 公共卫生 公共卫生

背景情况:

  • 晚年抑郁症和关节炎是普遍存在的,残疾条件.
  • 抑郁症加剧了关节炎患者的健康状况不佳.

研究的目的:

  • 评估是否增强抑郁症护理改善了老年抑郁症和关节炎并发症患者的疼痛和功能结果.

主要方法:

  • 随机对照试验"改善促进情绪的协作治疗" (IMPACT) 的子组分析.
  • 包括来自18个初级保健诊所的1001名患有抑郁症和关节炎的老年人 (>=60岁).
  • 干预涉及抗抑郁药物和/或在初级保健中解决问题的治疗;在12个月内评估结果.

主要成果:

  • 与通常护理相比,干预组12个月后的疼痛强度得分明显较低 (平均差异-0.53;P=.009).
  • 在干预组中,由于关节炎和疼痛而对日常活动的干扰也显著下降.
  • 接受增强抑郁症护理的患者的整体健康状况和生活质量得到改善.

结论:

  • 对患有关节炎的老年人进行增强的抑郁症护理,除了减轻症状之外,还能带来好处.
  • 改善抑郁症管理导致疼痛减轻和功能状态提高.
  • 协作治疗模式对这一群体的整体生活质量产生了积极的影响.