简单疹病毒在重症监护患者的呼吸道:一个前性研究
Peggy Bruynseels1, Philippe G Jorens, Hendrik E Demey
1Department of Microbiology, University Hospital of Antwerp, Antwerp, Belgium. peggy.bruynseels@uza.be
Lancet (London, England)
|November 15, 2003
概括
单纯疹病毒 (HSV) 在上呼吸道的重新激活在重症监护患者中很常见. 上呼吸道HSV增加了下呼吸道感染的风险,可能通过吸入.
科学领域:
- 关键护理医学 关键护理医学
- 病毒学 病毒学
- 传染病 传染病 传染病
背景情况:
- 在重症监护室 (ICU) 患者的下呼吸道中发现了简单疹病毒 (HSV),但其临床意义尚不清楚.
- 进行了一项前性队列研究,以调查HSV在重症患者呼吸道中的流行率,起源,风险因素和临床相关性.
研究的目的:
- 为了确定在ICU患者的呼吸道中HSV的流行率.
- 为了确定与呼吸道检测HSV相关的风险因素.
- 评估临床相关性和与重症患者的HSV存在相关的结果.
主要方法:
- 一组入院于ICU的764名患者被前性地测试了他们的呼吸道中的HSV.
- 进行了统计分析,以将HSV存在与各种临床变量和结果相关联.
主要成果:
- 在接受ICU治疗的10天内,在22%的患者的上呼吸道 (耳鼻水) 中检测到HSV.
- 在16%的样本患者中,HSV从下呼吸道中分离出来.
- 上呼吸道HSV是下呼吸道HSV感染的重要风险因素 (p<0.001),与严重疾病,急性呼吸困扰综合征和更长的ICU停留 (p<0.001) 相联系.
结论:
- 在ICU患者中,高呼吸道的HSV重新激活或感染是常见的.
- 上呼吸道HSV是发展下呼吸道HSV感染的危险因素,可能是通过吸入.
- 这些发现凸显了在重症患者中识别和潜在管理HSV的临床重要性.
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