炎症是心房动的一个危险因素
Ronnier J Aviles1, David O Martin, Carolyn Apperson-Hansen
1Department of Cardiovascular Medicine, Desk F15, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, Ohio 44951, USA.
Circulation
|November 19, 2003
概括
升高的C-反应蛋白 (CRP) 水平与心房动 (AF) 有关. 这项研究表明,CRP在大量人群中预测了AF的存在和未来发展.
科学领域:
- 心脏病学 心脏病学
- 炎症研究 炎症研究
- 流行病学 流行病学
背景情况:
- 系统性炎症,由高C反应蛋白 (CRP) 表示,与心房 (AF) 持久性有关.
- 对于AF的CRP的预测价值尚未在大型基于人口的队列中得到广泛研究.
研究的目的:
- 调查CRP水平与AF存在之间的关联.
- 确定CRP是否可以预测AF在大量人群中的未来发展.
主要方法:
- 心血管健康研究招募了5806名受试者,具有基线CRP测量和心血管评估.
- 实验对象的平均随访时间为6.9年,通过自我报告,心电图和医院出院诊断来确定AF.
- 单变量和多变量分析评估了CRP作为基线和事件AF的预测因素.
主要成果:
- 在基线时,CRP四分位数最高的受试者与最低四分位数相比,AF显著增加 (7.4%与3.7%,调整后OR1.8).
- 在随访期间,基线CRP升高预测了未来AF发展的风险更高 (最高和最低四分位数的调整HR为1.31).
- 被视为连续变量的CRP也预测了未来AF风险的增加 (调整后HR为1.24每1SD增加).
结论:
- C-反应蛋白 (CRP) 与当前心房动 (AF) 的存在有关.
- 升高的CRP水平可以预测未来患有AF风险增加的个体.
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