相关实验视频
Updated: May 2, 2026

07:34
Milk Collection Methods for Mice and Reeves' Muntjac Deer
Published on: July 19, 2014
19.8K
哺乳动物的甜味和乌玛米味道的受体
Grace Q Zhao1, Yifeng Zhang, Mark A Hoon
1Howard Hughes Medical Institute and Departments of Biology and Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA.
Cell
|November 26, 2003
概括
这项研究表明,T1R受体对于小鼠的甜味和乌玛米味觉是必不可少的. 消除特定的T1R子单元改变了味道检测,证明了它们在味道模式感知中的关键作用.
科学领域:
- 神经科学是一个神经科学.
- 感官生物学 感官生物学
- 遗传学 是一个遗传学.
背景情况:
- 甜味和乌玛米味道是人类关键的有吸引力的感官模式.
- T1R受体,特别是T1R1+3 (乌玛米) 和T1R2+3 (甜),是负责这些味道的候选G蛋白结合受体.
研究的目的:
- 描述T1R1,T1R2和T1R3在味觉感知中的行为和生理作用.
- 研究甜味识别和神经编码的分子基础.
主要方法:
- 产生和分析T1R1,T1R2和T1R3淘汰赛小鼠.
- 工程小鼠在甜味敏感细胞中表达人类T1R2 (hT1R2) 或改性阿片类受体 (RASSL).
主要成果:
- 甜味和乌玛米味道的感知完全依赖于T1R受体.
- 选择性删除T1R子单元差异性损害了甜味和乌玛米味道的检测和感知.
- 在小鼠中hT1R2的表达导致了类似人类的甜味偏好.
- 在甜细胞中RASSL的表达诱导了对合成阿片类药物的吸引.
结论:
- T1R受体对于甜味和乌玛米味道的检测和感知是不可或缺的.
- 甜味细胞的选择性是由它们表达的特定受体决定的,而不仅仅是细胞类型.
- 这些发现突出了T1R子单元在调解特定的味道模式和塑造味道偏好方面的关键作用.
相关概念视频
Tonicity in Animals
111.5K
The tonicity of a solution determines if a cell gains or loses water in that solution. The tonicity depends on the permeability of the cell membrane for different solutes and the concentration of nonpenetrating solutes in the solution within and outside of the cell. If a semipermeable membrane hinders the passage of some solutes but allows water to follow its concentration gradient, water moves from the side with low osmolarity (i.e., less solute) to the side with higher osmolarity (i.e.,...
111.5K
The Tongue and Taste Buds
34.7K
The surface of the tongue is covered with various small bumps called papillae, which either distribute what has been ingested (filiform papillae) or contain the sensory taste (or gustatory) receptor cells (fungiform, circumvallate, and foliate papillae). Embedded within each taste-related papilla are the taste buds—clusters of 30 to 100 gustatory receptor cells.
34.7K
Gustation
43.5K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
43.5K
Tonicity in Animals
9.0K
Tonicity describes the amount of solute in a solution. The measure of the tonicity of a solution, or the total amount of solutes dissolved in a specific amount of solution, is called its osmolarity. Three terms—hypotonic, isotonic, and hypertonic—are used to relate the osmolarity of a cell to the osmolarity of the extracellular fluid that contains the cells. In a hypotonic solution, such as tap water, the extracellular fluid has a lower concentration of solutes than the fluid inside...
9.0K
The Physiology of Taste
6.8K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
6.8K
The Mammary Glands
3.2K
The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
3.2K

