流感是一次流感
Karl G Nicholson1, John M Wood, Maria Zambon
1Infectious Diseases Unit, Leicester Royal Infirmary, Leicester, UK. karlgnicholson@doctors.org.uk
Lancet (London, England)
|December 4, 2003
概括
通过新的疫苗和抗病毒药物,流感控制取得了进展,改善了年度疫情管理. 持续的研究对于疫情准备和理解流感病原性至关重要.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,流感感染造成了严重的痛苦和经济损失.
- 几十年来,在流感控制方面取得的进展有限,直到最近的进展.
- 禽流感菌株 (H5N1,H9N2,H7N7) 构成流行病威胁.
研究的目的:
- 审查最近流感控制策略的进展.
- 强调疫苗接种和抗病毒疗法的重要性.
- 强调需要对流感大流行进行持续研究.
主要方法:
- 对非活化和活体流感病毒疫苗的证据的审查.
- 对疫苗技术发展的分析.
- 对神经氨基酶抑制剂的检查和临床检测.
主要成果:
- 无活化疫苗提供保护;活疫苗在儿童中是安全有效的.
- 现在可以使用针对神经氨基酶的强效抗病毒药物.
- 经济建模支持每年进行疫苗接种和抗病毒使用.
- 临近患者检测有助于诊断和监测.
结论:
- 最近疫苗和抗病毒药物的进展提高了流感管理.
- 新出现的禽流感菌株强调了流行病的脆弱性.
- 国际研究对于了解病原性和为流行病做好准备至关重要.
- 提高疫苗/抗病毒药物的监测和综合使用对于减少全球流感影响至关重要.
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