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相关概念视频

Mate Choice01:20

Mate Choice

Mate choice—the decision about whom to mate with—is a type of natural selection, since animals must reproduce to pass down their genes. Mate choice is also called intersexual selection because the behavior occurs between the sexes.
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Natural Selection and Mating Preferences01:06

Natural Selection and Mating Preferences

The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing, inherently...

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相关实验视频

Updated: Jul 16, 2026

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation
09:23

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation

Published on: February 13, 2017

一个细胞系可以诱导胸细胞阳性选择.

P Hugo1, J W Kappler, D I Godfrey

  • 1Howard Hughes Medical Institute, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.

Nature
|December 17, 1992
PubMed
概括

这项研究表明,特定的胸膜上皮细胞可以选择T细胞. 这些细胞通过主要基因相容性复合体 (MHC) 蛋白质呈现抗原,指导T细胞的发育.

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学

背景情况:

  • 胸腺对于T细胞发育至关重要,涉及积极选择.
  • 阳性选择确保T细胞识别自我主要基因相容性复合体 (MHC) 蛋白.
  • 调解胸膜阳性选择的特定细胞类型仍然不完全理解.

研究的目的:

  • 调查特殊的胸膜上皮细胞是否调解T细胞的阳性选择.
  • 为了确定是否引入的上皮细胞可以支持积极选择.

主要方法:

  • 照射过的小鼠用骨髓或胎儿肝细胞复制.
  • 在接受H-2k的小鼠中引入了一种表达H-2b的胸膜上皮细胞系.
  • 分析了T细胞受体的识别和限制.

主要成果:

  • 在接受动物中检测到I-Ab受限T细胞的存在.
  • 这表明,引入的表达H-2b的上皮细胞成功调解了积极选择.
  • 证明了特定上皮细胞在T细胞选择中的能力.

结论:

  • 特定的胸膜上皮细胞足以调解T细胞的阳性选择.
  • 这一发现澄清了胸腺内T细胞发育的细胞基础.

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Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
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An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells
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相关实验视频

Last Updated: Jul 16, 2026

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation
09:23

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation

Published on: February 13, 2017

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
10:38

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells
08:05

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

Published on: May 6, 2021

  • 突出了上皮细胞子集在适应性免疫中的作用.