的总合成 (--) -lemonomycincin 的
Eric R Ashley1, Ernest G Cruz, Brian M Stoltz
1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Journal of the American Chemical Society
|December 5, 2003
概括
研究人员首次实现了 (-) - - 莱莫诺米辛的总合成,这是一种新型的甘基化四化诺林抗瘤抗生素. 这种复杂的合成利用了关键反应,以高效地构建分子.
科学领域:
- 有机化学 有机化学
- 药用化学 医学化学
- 合成化学 合成化学
背景情况:
- (-) -Lemonomycin是一种新型的糖基化四化诺类抗生素,具有潜在的抗瘤特性.
- 复杂的结构 (-) - - 莱莫诺米辛提出了重要的合成挑战.
研究的目的:
- 实现首次全合成新型抗瘤抗生素 (-) - 莱莫诺米辛.
- 开发一种高效和融合的合成路径,以 (-) - - 莱莫诺米辛.
主要方法:
- 一个高度融合的合成涉及15个步骤.
- 关键反应包括不对称的双极循环加法,苏子基碎片合和立体选择性皮克特-斯勒反应.
- 这种新型的氨基糖化物是通过隔离选择的费尔金控制的乙醇添加合成的.
主要成果:
- 首次成功完成 (-) - - 莱莫诺米的总合成.
- 合成建立了aglycone核心的立体化学.
- 氨基糖化物子单元直接纳入核心结构,避免了后期的操纵.
结论:
- 开发的合成策略提供了一个有效的路线,以 (-) - - .
- 这种合成为进一步研究 (-) - - 莱莫诺米辛的生物活性开辟了道路.
- 该方法可能适用于合成相关的复杂自然产品.
更多相关视频
07:12Determination of Self-(In)compatibility and Inter-(In)compatibility Relationships in Citrus Using Manual Pollination, Microscopy, and S-Genotype Analyses
Published on: June 30, 2023
08:07Analysis of the Expression and Complexes Assembly of the Mitochondrial Respiratory Chain Proteins in the Fission Yeast Schizosaccharomyces pombe
Published on: May 2, 2025
相关概念视频
Products of the Citric Acid Cycle
The cells of most organisms—including plants and animals—obtain usable energy through aerobic respiration, the oxygen-requiring version of cellular respiration. Aerobic respiration consists of four major stages: glycolysis, pyruvate oxidation, the citric acid cycle, and oxidative phosphorylation. The third major stage, the citric acid cycle, is also known as the Krebs cycle or tricarboxylic acid (TCA) cycle.
Weak Acid Solutions
Few compounds act as strong acids. A far greater number of compounds behave as weak acids and only partially react with water, leaving a large majority of dissolved molecules in their original form and generating a relatively small amount of hydronium ions. Weak acids are commonly encountered in nature, being the substances partly responsible for the tangy taste of citrus fruits, the stinging sensation of insect bites, and the unpleasant smells associated with body odor. A familiar example of a...
Mixtures of Acids
The pH of a solution containing an acid can be determined using its acid dissociation constant and its initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending upon the relative strength of the acids and their dissociation constants.
A Mixture of a Strong Acid and a Weak Acid
In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...
A Mixture of a Strong Acid and a Weak Acid
In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...
Polyprotic Acids
Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
Mixtures of Acids
The pH of a solution containing an acid can be determined using its acid dissociation constant and initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending on the relative strength of the acids and their dissociation constants.
In a strong and weak acid mixture, the strong acid dissociates completely and becomes a source of almost all the hydronium ions present in the solution. In contrast, the weak acid shows...
In a strong and weak acid mixture, the strong acid dissociates completely and becomes a source of almost all the hydronium ions present in the solution. In contrast, the weak acid shows...
Combining Functions
Functions can be combined to form new mathematical models that describe interactions between variables. These combinations are fundamental in understanding relationships between changing quantities and are commonly encountered in scientific and engineering contexts. The combination methods—addition, subtraction, multiplication, division, and composition—each have unique implications for the resulting function’s domain and behavior.When combining functions through arithmetic operations, such...
